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Hum Cell. 2016 Apr;29(2):83-90. doi: 10.1007/s13577-015-0130-6. Epub 2016 Jan 6.

The advantages of incorporating liquid-based cytology (TACAS™) in mass screening for cervical cancer.

Author information

1
Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan. yokoyama@hirosaki-u.ac.jp.
2
Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
3
Department of Pathologic Analysis, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori, Japan.
4
Department of Medical Technology, Aomori General Health Examination Center, Aomori, Japan.
5
Department of Obstetrics and Gynecology, Misawa City Hospital, Misawa, Aomori, Japan.
6
Department of Obstetrics and Gynecology, Mutsu General Hospital, Mutsu, Aomori, Japan.

Abstract

We incorporated liquid-based cytology (LBC) in population-based screening for cervical cancer. The usefulness of using LBC in mass screening for cervical cancer was examined. From 2009 to 2014, 157,061 individuals underwent mass screening for cervical cancer in Aomori Prefecture. From 2009 to 2011, cells were collected from 82,218 individuals and the specimens were conventionally prepared (CP). From 2012 to 2014, cells were collected from 74,843 individuals and the specimens were prepared using LBC (TACAS™). Cytology results for the 2 sets of specimens were compared and differences in cytologic features were examined. ASC-US and more severe lesions were detected at a rate of 1.13 % by CP and 1.44 % by LBC, so LBC had a 1.3-fold higher rate of detection. LBC had a 1.6-fold higher rate of LSIL detection and a 1.2-fold higher rate of HSIL detection. CP detected cancer in 20 cases at a rate of 0.024 % while LBC detected cancer in 18 cases at a rate of 0.024 %. Cytodiagnosis of the 18 cases of SCC that LBC identified revealed that 7 were SCC, 8 were HSIL, and 3 were ASC-H. Atypical cells tended to be smaller with TACAS™. LBC reduced the time needed for microscopic examination of a single specimen by 42 % in comparison to CP. LBC using TACAS™ allowed the detection of slight lesions and slight changes in cells. LBC can lessen the burden on medical personnel and may lead to improved accuracy.

KEYWORDS:

Cervical cancer; Liquid-based cytology; Mass screening; TACAS™

PMID:
26739336
DOI:
10.1007/s13577-015-0130-6
[Indexed for MEDLINE]

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