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ACS Nano. 2016 Jan 26;10(1):1060-6. doi: 10.1021/acsnano.5b06383. Epub 2016 Jan 11.

Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications.

Author information

1
State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian, 116012, People's Republic of China.
2
Department of Materials Science & Engineering, Zhejiang University , Hangzhou, 310027, People's Republic of China.
3
Materials Sciences, Physical and Computational Sciences Directorate, Pacific Northwest National Laboratory , Richland, Washington 99352, United States.
4
Chemical Engineering Department, University of Massachusetts , Amherst, Massachusetts 01003, United States.
5
The Molecular Foundry, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.

Abstract

Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb(3+)) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.

KEYWORDS:

bioimaging; core/active shell structure; dye-sensitizing; near-infrared; optogenetics; upconversion nanoparticles

PMID:
26736013
PMCID:
PMC4913696
DOI:
10.1021/acsnano.5b06383
[Indexed for MEDLINE]
Free PMC Article

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