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Med Sci Monit. 2016 Jan 6;22:57-60.

T-SPOT.TB in Detection of Active Tuberculosis During Pregnancy: A Retrospective Study in China.

Author information

1
Department of Clinical Laboratory, Guangxi Maternal and Child Health Hospital, Nanning, Guangxi, China (mainland).
2
Department of Laboratory Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (mainland).
3
Department of Laboratory Medicine, Shandong Provincial Chest Hospital, Jinan, Shandong, China (mainland).

Abstract

BACKGROUND:

Interferon-gamma release assays have not been validated in active TB among pregnant women. Therefore, the objective of this retrospective study was to estimate the diagnostic value of T-SPOT.TB in active TB among pregnant women.

MATERIAL/METHODS:

Between May 2012 and May 2015, 26 consecutive pregnant women with suspected TB were enrolled in our study. The clinicopathological characteristics and T-SPOT.TB results were reviewed and analyzed.

RESULTS:

Pregnant patients were divided into a TB group (n=21) and a Non-TB group (n=5). In the TB group, 5 patients had pulmonary TB, 5 had pulmonary TB+ extrapulmonary TB, and 11 had exclusively extrapulmonary TB. The most common site of extrapulmonary TB was pleural (n=11). Statistical analysis showed that the lymphocyte count in the TB group was lower than in the Non-TB group (P<0.05). For detection of active TB during pregnancy, T-SPOT.TB had a high sensitivity of 100.0% (84.5%-100.0%) and a specificity of 80.0% (37.6-96.4%).

CONCLUSIONS:

T-SPOT.TB shows good performance in detection of active tuberculosis during pregnancy. Interferon gamma release assay for TB screening of pregnant women is recommended in clinical practice because it may be a more appropriate diagnostic tool than the tuberculin skin test.

PMID:
26732770
PMCID:
PMC4708096
DOI:
10.12659/msm.896943
[Indexed for MEDLINE]
Free PMC Article

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