Format

Send to

Choose Destination
Addict Biol. 2017 May;22(3):791-801. doi: 10.1111/adb.12338. Epub 2016 Jan 5.

Activation of the ventral and dorsal striatum during cue reactivity in Internet gaming disorder.

Author information

1
Institute of Developmental Psychology, Beijing Normal University, Beijing, 100875, China.
2
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06519, USA.
3
CASA Columbia, Yale University School of Medicine, New Haven, CT, 06519, USA.
4
State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
5
Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China.

Abstract

Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of both substance and behavioral addictions. Thirty-nine male Internet gaming disorder (IGD) subjects and 23 male matched healthy controls (HCs) participated in functional magnetic resonance imaging during performance of a cue-reactivity task involving alternating presentation of Internet gaming-related stimuli (game cues) and general Internet surfing-related stimuli (control cues). Cue-induced neural activations in the ventral and dorsal striatum (DS) were compared between IGD and HC participants. Associations between cue-reactivity within these regions and cue-induced craving and severity and duration of IGD were also explored. IGD participants exhibited higher cue-induced activations within both the ventral and DS when compared with HCs. Within the IGD group, activity within the left ventral striatum (VS) was correlated negatively with cue-induced craving; positive associations were found between activations within the DS (right putamen, pallidum and left caudate) and duration of IGD. Cue-induced activity within the left putamen was negatively associated with right VS volumes among IGD participants. Consistent with studies in substance addictions, our results suggest that a transition from ventral to dorsal striatal processing may occur among individuals with IGD, a condition without the impact of substance intake.

KEYWORDS:

Internet gaming disorder; cue-reactivity; dorsal striatum; fMRI; ventral striatum

PMID:
26732520
PMCID:
PMC5563850
DOI:
10.1111/adb.12338
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center