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Curr Opin Microbiol. 2016 Apr;30:8-15. doi: 10.1016/j.mib.2015.12.001. Epub 2015 Dec 28.

Bacterial chemotaxis: information processing, thermodynamics, and behavior.

Author information

1
Department of Life Sciences, Imperial College, London, United Kingdom; Centre for Integrative Systems Biology and Bioinformatics, Imperial College, London, United Kingdom.
2
Department of Life Sciences, Imperial College, London, United Kingdom; Centre for Integrative Systems Biology and Bioinformatics, Imperial College, London, United Kingdom. Electronic address: r.endres@imperial.ac.uk.

Abstract

Escherichia coli has long been used as a model organism due to the extensive experimental characterization of its pathways and molecular components. Take chemotaxis as an example, which allows bacteria to sense and swim in response to chemicals, such as nutrients and toxins. Many of the pathway's remarkable sensing and signaling properties are now concisely summarized in terms of design (or engineering) principles. More recently, new approaches from information theory and stochastic thermodynamics have begun to address how pathways process environmental stimuli and what the limiting factors are. However, to fully capitalize on these theoretical advances, a closer connection with single-cell experiments will be required.

PMID:
26731482
DOI:
10.1016/j.mib.2015.12.001
[Indexed for MEDLINE]
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