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Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.top080754. doi: 10.1101/pdb.top080754.

BioGRID: A Resource for Studying Biological Interactions in Yeast.

Author information

1
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
2
Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada;
3
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
4
School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
5
Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.

Abstract

The Biological General Repository for Interaction Datasets (BioGRID) is a freely available public database that provides the biological and biomedical research communities with curated protein and genetic interaction data. Structured experimental evidence codes, an intuitive search interface, and visualization tools enable the discovery of individual gene, protein, or biological network function. BioGRID houses interaction data for the major model organism species--including yeast, nematode, fly, zebrafish, mouse, and human--with particular emphasis on the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe as pioneer eukaryotic models for network biology. BioGRID has achieved comprehensive curation coverage of the entire literature for these two major yeast models, which is actively maintained through monthly curation updates. As of September 2015, BioGRID houses approximately 335,400 biological interactions for budding yeast and approximately 67,800 interactions for fission yeast. BioGRID also supports an integrated posttranslational modification (PTM) viewer that incorporates more than 20,100 yeast phosphorylation sites curated through its sister database, the PhosphoGRID.

PMID:
26729913
PMCID:
PMC5975956
DOI:
10.1101/pdb.top080754
[Indexed for MEDLINE]
Free PMC Article

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