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Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.prot088880. doi: 10.1101/pdb.prot088880.

Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions.

Author information

1
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
2
Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada;
3
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
4
School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
5
Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.

Abstract

The BioGRID database is an extensive repository of curated genetic and protein interactions for the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and the yeast Candida albicans SC5314, as well as for several other model organisms and humans. This protocol describes how to use the BioGRID website to query genetic or protein interactions for any gene of interest, how to visualize the associated interactions using an embedded interactive network viewer, and how to download data files for either selected interactions or the entire BioGRID interaction data set.

PMID:
26729909
PMCID:
PMC5975959
DOI:
10.1101/pdb.prot088880
[Indexed for MEDLINE]
Free PMC Article

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