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Sensors (Basel). 2015 Dec 31;16(1). pii: E51. doi: 10.3390/s16010051.

Blood Group Typing: From Classical Strategies to the Application of Synthetic Antibodies Generated by Molecular Imprinting.

Author information

1
Department of Analytical Chemistry, University of Vienna, Währinger Straße 38, A-1090 Vienna, Austria. adnanmujahid.chem@pu.edu.pk.
2
Institute of Chemistry, University of the Punjab, Quaid-i-Azam Campus Lahore 54590, Pakistan. adnanmujahid.chem@pu.edu.pk.
3
Department of Analytical Chemistry, University of Vienna, Währinger Straße 38, A-1090 Vienna, Austria. Franz.Dickert@univie.ac.at.

Abstract

Blood transfusion requires a mandatory cross-match test to examine the compatibility between donor and recipient blood groups. Generally, in all cross-match tests, a specific chemical reaction of antibodies with erythrocyte antigens is carried out to monitor agglutination. Since the visual inspection is no longer useful for obtaining precise quantitative information, therefore there is a wide variety of different technologies reported in the literature to recognize the agglutination reactions. Despite the classical methods, modern biosensors and molecular blood typing strategies have also been considered for straightforward, accurate and precise analysis. The interfacial part of a typical sensor device could range from natural antibodies to synthetic receptor materials, as designed by molecular imprinting and which is suitably integrated with the transducer surface. Herein, we present a comprehensive overview of some selected strategies extending from traditional practices to modern procedures in blood group typing, thus to highlight the most promising approach among emerging technologies.

KEYWORDS:

ABO-blood group typing; agglutination; molecular imprinting; synthetic receptors

PMID:
26729127
PMCID:
PMC4732084
DOI:
10.3390/s16010051
[Indexed for MEDLINE]
Free PMC Article

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