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Leuk Lymphoma. 2016 Sep;57(9):2071-6. doi: 10.3109/10428194.2015.1128542. Epub 2016 Jan 4.

Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients.

Author information

1
a Jagiellonian University Medical College , Cracow , Poland ;
2
b Wroclaw Medical University , Wroclaw , Poland ;
3
c Santa Casa Medical School , Sao Paulo , Brazil ;
4
d University Hospital Olomouc , Olomouc , Czech Republic ;
5
e Department of Hematology University Hospitals Leuven , Belgium ;
6
f Hopital La Miletrie, CHU Poitiers , France ;
7
g Department of Internal Medicine II , University Hospital Wuerzburg , Wuerzburg , Germany ;
8
h Winship Cancer Institute, Emory University , Atlanta , GA , USA ;
9
i Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology , Warsaw , Poland ;
10
j Hospital Universitario De Salamanca , Salamanca , Spain ;
11
k Centre Hospitalier Universitaire De Liege , Liege , Belgium ;
12
l Department of Medicine - Haematology , Hradec Kralove , Czech Republic ;
13
m Division of Hematology , Mayo Clinic , Rochester , MN , USA ;
14
n Hematology Unit, Department of Onco-Hematology , A.O. of Cosenza , Cosenza , Italy ;
15
o Hospital Italiano De Buenos Aires , Buenos Aires , Argentina ;
16
p Haematology, Ospedale A. Perrino , Brindisi , Italy ;
17
q John Theurer Cancer Center at Hackensack University Medical Center , Hackensack , NJ , USA ;
18
r Massachusetts General Hospital Cancer Center , Harvard Medical School , Boston , MA , USA ;
19
s Royal Victoria Hospital, McGill University , Montreal , Canada ;
20
t Columbia University Medical Center , New York , NY , USA ;
21
u VU University Medical Center , Amsterdam , the Netherlands ;
22
v Azienda Ospedaliera Universitaria Senese , Siena , Italy ;
23
w Dana-Farber Cancer Institute, Harvard Medical School , Boston , MA , USA.

Abstract

Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical outcomes, immunohistochemistry and cytogenetic features, and relevant laboratory data on 53 biopsy-proven skin MM cases. The median time from MM diagnosis to skin involvement was 2 years. There appears to be an overrepresentation of immunoglobulin class A (IgA) and light chain disease in skin MM. We found no correlation between CD56 negative MM and skin infiltration. We found that skin MM patients presented in all MM stages (i.e. ISS stages I to III), and there was no preferential cytogenetic abnormality. Patients with skin MM carry a very poor prognosis with a median overall survival (OS) of 8.5 months as time from skin involvement. Moreover, patients with IgA disease and plasmablastic morphology appear to have a worse OS.

KEYWORDS:

Cutaneous; diagnosis; myeloma; skin; treatment

PMID:
26726867
DOI:
10.3109/10428194.2015.1128542
[Indexed for MEDLINE]

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