Format

Send to

Choose Destination
Immunobiology. 2016 Apr;221(4):512-5. doi: 10.1016/j.imbio.2015.12.008. Epub 2015 Dec 18.

The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis.

Author information

1
ILiAD Biotechnologies, 230 East 15th Street, #1-A, New York, NY 10003, United States. Electronic address: keith@iliadbio.com.
2
ILiAD Biotechnologies, 230 East 15th Street, #1-A, New York, NY 10003, United States. Electronic address: glazer@iliadbio.com.

Abstract

It is established that (1) subclinical Bordetella pertussis colonization of the nasopharynx persists in highly vaccinated populations, and (2) B. pertussis toxin is a potent adjuvant that, when co-administered with neural antigens, induces neuropathology in experimental autoimmune encephalomyelitis, the principle animal model of multiple sclerosis. Building on these observations with supporting epidemiologic and biologic evidence, we propose that, contrary to conventional wisdom that subclinical pertussis infections are innocuous to hosts, B. pertussis colonization is an important cause of multiple sclerosis.

KEYWORDS:

Bordetella pertussis; Bordetella pertussis toxin; Etiology; Multiple sclerosis

PMID:
26724970
DOI:
10.1016/j.imbio.2015.12.008
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center