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Int J Biol Macromol. 2016 Apr;85:1-8. doi: 10.1016/j.ijbiomac.2015.12.064. Epub 2015 Dec 24.

Multilayer sodium alginate beads with porous core containing chitosan based nanoparticles for oral delivery of anticancer drug.

Author information

1
College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China.
2
Qingdao Municipal Hospital, Qingdao 266003, PR China.
3
College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China. Electronic address: fengchao@ouc.edu.cn.
4
College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China. Electronic address: xgchen@ouc.edu.cn.

Abstract

To develop efficient and safe anticancer drug doxorubicin hydrochloride (DOX) delivery system for oral chemotherapy, chitosan based nanoparticles (CS/CMCS-NPs) composed of chitosan (CS) and o-carboxymeymethy chitosan (CMCS) were immobilized in multilayer sodium alginate beads (NPs-M-Beads). Two kinds of NPs-M-Beads, with or without porous core, were respectively prepared by internal or external ionic gelation method. In the small intestine, the intact CS/CMCS-NPs were able to escape from porous-beads and sustained release the loading DOX. In vivo results showed that the DOX could be efficiently absorbed by small intestine of SD rat and the higher concentration of the DOX in major organs of rats were found after oral administration of Porous-Beads, which were about 2-4 folds higher than that of non-porous-beads. These results suggested that the NPs-M-Beads with porous core to be exciting and promising for oral delivery of DOX.

KEYWORDS:

Chitosan; External crosslinking; Internal crosslinking; Porous-beads; Sustained release

PMID:
26724684
DOI:
10.1016/j.ijbiomac.2015.12.064
[Indexed for MEDLINE]

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