Format

Send to

Choose Destination
Am J Pathol. 2016 Mar;186(3):500-6. doi: 10.1016/j.ajpath.2015.12.001. Epub 2015 Dec 24.

Precision Medicine: Clarity for the Complexity of Dementia.

Author information

1
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
2
Group Health Research Institute, Seattle, Washington.
3
Department of Neurology, Oregon Health and Science University, Portland, Oregon; Portland Veterans Affairs Medical Center, Portland, Oregon.
4
Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Parkinson's Disease Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Department of Neurology, University of Washington, Seattle, Washington.
5
Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Department of Neurology, University of Washington, Seattle, Washington.
6
Department of Pathology, University of Washington, Seattle, Washington.
7
Department of Medicine, University of Washington, Seattle, Washington.
8
Department of Neurology, University of Washington, Seattle, Washington; Department of Radiology, University of Washington, Seattle, Washington.
9
Department of Pathology, University of Washington, Seattle, Washington. Electronic address: tmontine@uw.edu.

Abstract

Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

PMID:
26724389
PMCID:
PMC4816691
DOI:
10.1016/j.ajpath.2015.12.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center