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Stroke. 1989 Sep;20(9):1273-5.

Action of magnesium sulfate in the treatment of preeclampsia-eclampsia.

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Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel.


Recent evidence supports the concept that cerebral vasospasm is involved in the pathogenesis of eclampsia. Magnesium, which has a beneficial effect in eclampsia, may act by opposing calcium-dependent arterial constriction, thereby relieving vasospasm. Magnesium may also antagonize the increase in intracellular calcium concentration caused by ischemia and thus prevent cell damage and death. Magnesium might have a role in the treatment of cerebral vasospasm and ischemia, such as occurs in subarachnoid hemorrhage, ischemic stroke, and brain trauma.

[Indexed for MEDLINE]

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