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Autoimmun Rev. 2016 Apr;15(4):335-43. doi: 10.1016/j.autrev.2015.12.006. Epub 2015 Dec 23.

Vitiligo: Pathogenesis, clinical variants and treatment approaches.

Author information

1
Organi di Senso Department, Sapienza University of Rome, Viale del Policlinico 151, 00161 Rome, Italy. Electronic address: giannicolaiannella@hotmail.it.
2
Organi di Senso Department, Sapienza University of Rome, Viale del Policlinico 151, 00161 Rome, Italy. Electronic address: antonio.greco@uniroma1.it.
3
First Dermatology Division, Institute Dermopatico dell'Immacolata (I.D.I.) - IRCCS, Via Monti di Creta 104, 00167 Rome, Italy. Electronic address: dario.didona@gmail.com.
4
First Dermatology Division, Institute Dermopatico dell'Immacolata (I.D.I.) - IRCCS, Via Monti di Creta 104, 00167 Rome, Italy. Electronic address: b.didona@idi.it.
5
Department of Clinical Immunology, Sapienza University of Rome, Viale dell'Università 37, 00161 Rome, Italy. Electronic address: guido.granata@alice.it.
6
Organi di Senso Department, Sapienza University of Rome, Viale del Policlinico 151, 00161 Rome, Italy. Electronic address: alessandramanno@hotmail.it.
7
Organi di Senso Department, Sapienza University of Rome, Viale del Policlinico 151, 00161 Rome, Italy. Electronic address: benedetta.pasquariello@gmail.com.
8
Organi di Senso Department, Sapienza University of Rome, Viale del Policlinico 151, 00161 Rome, Italy. Electronic address: giuseppemagliuloorl@yahoo.com.

Abstract

Vitiligo is a common chronic acquired disease of pigmentation whose etiology is unknown, which usually occurs with asymptomatic whitish patch or macule. Although several hypotheses have been proposed in the literature, the leading theory is still the auto-immune etiology linked to specific genetic mutations. Vitiligo can also be associated with several autoimmune diseases, including autoimmune thyroid diseases, alopecia areata, and halo nevi. Sensorineural hearing loss was reported in several vitiligo patients due to a reduction in the number of melanocytes contained in the membranous labyrinth of the inner ear. Because of its complexity, several therapeutic options are available to treat this systemic disease.

KEYWORDS:

Autoimmune diseases; Hearing loss; NB-UVB; Oxidative stress; Prednisolone; Vitiligo

PMID:
26724277
DOI:
10.1016/j.autrev.2015.12.006
[Indexed for MEDLINE]

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