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Eur J Pharmacol. 2016 Feb 5;772:124-30. doi: 10.1016/j.ejphar.2015.12.042. Epub 2015 Dec 23.

Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation.

Author information

1
Department of Family Medicine, College of Medicine, Dong-A University, Busan 604-714, Republic of Korea; Department of Emergency, Heilongjiang Provincial Hospital, Harbin 150000, China.
2
Department of gynaecology and obstetrics, Heilongjiang Provincial Hospital, Harbin 150000, China.
3
Department of Emergency, Heilongjiang Provincial Hospital, Harbin 150000, China.
4
Department of Nephrology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150000, China.
5
Department of Family Medicine, College of Medicine, Dong-A University, Busan 604-714, Republic of Korea. Electronic address: lichengzhen12@163.com.

Abstract

Eriodictyol, a flavonoid present in citrus fruits, has been reported to have antioxidant and anti-inflammatory effects. In this study, the protective effects of eriodictyol on cisplatin (CP)-induced kidney injury were detected. CP-induced kidney injury model was established by administration of CP (20mg/kg). The results showed that treatment of eriodictyol inhibited the production of blood urea nitrogen (BUN), creatinine, MDA, TBARS, reactive oxygen species (ROS), as well as the production of TNF-α, and IL-1β in kidney tissues induced by CP. Eriodictyol also up-regulated the activities of SOD, CAT, and GSH-PX decreased by CP. Furthermore, eriodictyol was found to up-regulate the expression of Nrf2/HO-1 and inhibited CP-induced NF-κB activation in kidney tissues. In conclusion, eriodictyol protected against CP-induced kidney injury through activating Nrf2 and inhibiting NF-κB activation.

KEYWORDS:

Cisplatin; Eriodictyol; Kidney injury; NF-κB; Nrf2

PMID:
26723515
DOI:
10.1016/j.ejphar.2015.12.042
[Indexed for MEDLINE]

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