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Science. 1989 Sep 8;245(4922):1054-8.

Dictyostelium discoideum: a model system for cell-cell interactions in development.

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Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.


The cellular slime mold Dictyostelium discoideum undergoes a transition from single-celled amoebae to a multicellular organism as a natural part of its life cycle. A method of cell-cell signaling that controls chemotaxis, morphogenesis, and gene expression has developed in this organism, and a detailed understanding of this signaling system provides clues to mechanisms of intercellular communication in the development of metazoans.

[Indexed for MEDLINE]

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