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Biomater Res. 2015 Dec 31;19:14. doi: 10.1186/s40824-015-0036-0. eCollection 2015.

Long and short range order structural analysis of In-situ formed biphasic calcium phosphates.

Author information

1
School of Materials Science and Engineering, Pusan National University, Busan, 609-735 Republic of Korea.
2
School of Nano and Advanced Materials, Gyeongsang National University, Jinju, Gyeongnam 660-701 Republic of Korea.
3
Korea Institute of Industrial Technology, Busan, 618-230 Republic of Korea.

Abstract

BACKGROUND:

Biphasic calcium phosphates (BCP) have attracted considerable attention as a bone graft substitute. In this study, BCP were prepared by aqueous co-precipitation and calcination method. The crystal phases of in-situ formed BCP consisting of hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) were controlled by the degree of calcium deficiency of precursors. The long and short range order structures of biphasic mixtures was investigated using Rietveld refinement technique and high resolution Raman spectroscopy. The refined structural parameters of in-situ formed BCP confirmed that all the investigated structures have crystallized in the corresponding hexagonal (space group P63/m) and rhombohedral (space group R3c) structures.

RESULTS:

The crystal phases, Ca/P molar ratio, and lattice parameters of in-situ formed BCP consisting of HAp and β-TCP were controlled by the degree of calcium deficiency of calcium phosphate precursors. The significant short range order structural change of BCP was determined by Raman analysis.

CONCLUSIONS:

The long and short range order structural changes of in-situ formed BCP might be due to the coexistence of β-TCP and HAp crystal phases.

KEYWORDS:

Biphasic calcium phosphate; Raman spectroscopy; Rietveld refinement

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