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Anticancer Res. 2016 Jan;36(1):343-9.

Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma.

Author information

1
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China The Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
2
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
3
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China Department of Pathology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
4
Department of Oncology, Anyang Tumour Hospital, Anyang, Henan, P.R. China.
5
Department of Surgery, Anyang Tumour Hospital, Anyang, Henan, P.R. China.
6
Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, University of Oslo, Montebello, Oslo, Norway Department of Pathology, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
7
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
8
The Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
9
Department of Surgery, The Norwegian Radium Hospital, Oslo University Hospital, University of Oslo, Montebello, Oslo, Norway.
10
Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, University of Oslo, Montebello, Oslo, Norway.
11
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, University of Oslo, Montebello, Oslo, Norway Department of Pathology, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway zhenhes@medisin.uio.no zhenhesuo@aliyun.com.

Abstract

BACKGROUND:

Aldehyde dehydrogenase-1 (ALDH1) has been shown to be a potential cancer stem cell marker in different types of cancer. However, the role of its expression in tumor cells and the microenvironment in different types of cancer is still controversial.

MATERIALS AND METHODS:

ALDH1 protein was immunohistochemically investigated and analyzed in 157 samples of surgically dissected esophageal squamous cell carcinoma (ESCC) tissues.

RESULTS:

ALDH1 protein expression in ESCC tumor cells was significantly associated with poor differentiation (p<0.05) and strongly positive ALDH1 expression in tumor cells was related with shorter overall survival (p<0.05), while the expression of ALDH1 in ESCC stromal cells had no significant relationship with clinicopathological features (p>0.05).

CONCLUSION:

High expression of cancer stem cell marker ALDH1 in ESCC cells may thus portend a poor prognosis. However, its expression in the tumor microenvironment did not appear to have a role in ESCC behavior. More studies are warranted to find out the mechanisms to explain this.

KEYWORDS:

Aldehyde dehydrogenase-1; esophageal squamous cell carcinoma; immunohistochemistry; prognosis

PMID:
26722063
[Indexed for MEDLINE]

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