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Fetal Pediatr Pathol. 2016;35(1):1-9. doi: 10.3109/15513815.2015.1122121. Epub 2015 Dec 31.

Maternal Coffee Consumption During Pregnancy and Neural Tube Defects in Offspring: A Meta-Analysis.

Author information

1
a The Second Hospital of Shandong University , Jinan , China.
2
b Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , China.

Abstract

PURPOSE:

To examine the association between maternal coffee consumption during pregnancy and the occurrence of neural tube defects (NTDs) in offspring.

METHODS:

PubMed, Springer Link and Elsevier databases were searched up to August, 2014. Case-control and cohort studies published on the association between maternal coffee consumption during pregnancy and the occurrence of NTDs in offspring were included. Meta-analysis was applied to calculate the pooled effect estimates and their 95% confidence intervals (CIs) using a random-effects model.

RESULTS:

A total of six case-control studies and one cohort study were included. The pooled effect estimate of maternal coffee consumption during pregnancy was 0.86 for total NTDs (95% CI: 0.51- 1.45) and 1.30 (95% CI: 0.67- 2.52) for NTDs subtype of spina bifida.

CONCLUSIONS:

Our findings suggested that maternal coffee consumption during pregnancy was not significantly associated with the occurrence of total NTD or the spina bifida subtype of NTD.

KEYWORDS:

coffee; meta-analysis; neural tube defects; pregnancy

PMID:
26720182
DOI:
10.3109/15513815.2015.1122121
[Indexed for MEDLINE]

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