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Open Forum Infect Dis. 2015 Nov 25;2(4):ofv178. doi: 10.1093/ofid/ofv178. eCollection 2015 Dec.

Minocycline as A Substitute for Doxycycline in Targeted Scenarios: A Systematic Review.

Author information

1
Department of Pharmacotherapeutics and Clinical Research , University of South Florida College of Pharmacy ; Departments of Family Medicine.
2
Department of Pharmacy , North Florida/South Georgia Veterans Health System , Gainesville.
3
Internal Medicine , University of South Florida, Morsani College of Medicine , Tampa.
4
Department of Pharmacotherapeutics and Clinical Research , University of South Florida College of Pharmacy ; Internal Medicine , University of South Florida, Morsani College of Medicine , Tampa.

Abstract

Doxycycline, a commonly prescribed tetracycline, remains on intermittent shortage. We systematically reviewed the literature to assess minocycline as an alternative to doxycycline in select conditions, given doxycycline's continued shortage. We identified 19 studies, 10 of which were published before 2000. Thirteen of the studies were prospective, but only 1 of these studies was randomized. Based on the available data, we found minocycline to be a reasonable substitute for doxycycline in the following scenarios: skin and soft-tissue infections and outpatient treatment of community-acquired pneumonia in young, otherwise healthy patients or in patients with macrolide-resistant Mycoplasma pneumoniae, as well as Lyme disease prophylaxis and select rickettsial disease should doxycycline be unavailable.

KEYWORDS:

alternatives; doxycycline; minocycline; shortage; substitution

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