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J Cardiovasc Transl Res. 2016 Feb;9(1):85-6. doi: 10.1007/s12265-015-9669-6. Epub 2015 Dec 30.

Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy.

Author information

1
Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA.
2
Department of Neurology, School of Medicine, University of Missouri, Columbia, MO, USA.
3
Departments of Physiology & Cell Biology and Molecular & Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH, USA.
4
Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
5
The Johns Hopkins University Medical Institutions, Baltimore, MD, USA.
6
Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
7
Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
8
Division of Cardiology and Center for Genetic Medicine Research, Children's National Heart Institute, Children's National Health System, Washington, DC, USA.
9
Parent Project Muscular Dystrophy, Middletown, OH, USA. kathi@parentprojectmd.org.

Abstract

A recent working group meeting focused on contemporary cardiac issues in Duchenne muscular dystrophy (DMD) was hosted by the National Heart, Lung, and Blood Institute in collaboration with the Parent Project Muscular Dystrophy. An outcome of this meeting was to provide freely available detailed protocols for preclinical animal studies. The goal of these protocols is to improve the quality and reproducibility of cardiac preclinical studies aimed at developing new therapeutics for the prevention and treatment of DMD cardiomyopathy.

KEYWORDS:

Cardiology; Cardiomyopathy; Duchenne; Preclinical; Standard operating procedures (SOPs)

PMID:
26718928
PMCID:
PMC5509361
DOI:
10.1007/s12265-015-9669-6
[Indexed for MEDLINE]
Free PMC Article

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