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J Thorac Oncol. 2016 Feb;11(2):261-5. doi: 10.1016/j.jtho.2015.10.021. Epub 2015 Dec 22.

Frequent BRAF or EGFR Mutations in Ciliated Muconodular Papillary Tumors of the Lung.

Author information

1
Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan; Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan; Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan.
2
Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
3
Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
4
Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
5
Division of Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
6
Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan; Division of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan.
7
Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
8
Department of Surgery, Division of General Thoracic Surgery, School of Medicine, Keio University, Tokyo, Japan.
9
Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan; Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan. Electronic address: tsutakoj@hirakata.kmu.ac.jp.

Abstract

INTRODUCTION:

Ciliated muconodular papillary tumors (CMPTs) are recently characterized, rare peripheral nodules of the lung. These small tumors are histologically comprised of a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, and consistently follow a benign clinical course. However, the histogenesis of CMPTs remains uncertain.

METHODS:

We performed detailed genomic analyses of 10 archived CMPT cases, using next-generation sequencing and high-resolution melting analysis.

RESULTS:

Mutations were identified in eight of the 10 cases (80%); four cases harbored the BRAF-V600E mutation, one case harbored the BRAF-G606R mutation, and three cases harbored deletions in exon 19 of EGFR. All of the deletions in EGFR were of the E746-T751/S752V subtype.

CONCLUSIONS:

The high prevalence of driver gene mutations in CMPTs supports the notion that these lesions are neoplastic rather than reactive or metaplastic.

KEYWORDS:

BRAF; Ciliated muconodular papillary tumors; EGFR; Histogenesis; Next-generation sequencing

PMID:
26718882
DOI:
10.1016/j.jtho.2015.10.021
[Indexed for MEDLINE]
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