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Cell Mol Life Sci. 2016 Mar;73(6):1225-36. doi: 10.1007/s00018-015-2119-4. Epub 2015 Dec 30.

Exploring NAD+ metabolism in host-pathogen interactions.

Author information

1
Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
2
ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
3
CNRS FR 3636, Université Paris Descartes, 75006, Paris, France.
4
MIVEGEC (IRD 224-CNRS 5290-Université Montpellier), Institut de Recherche pour le Développement (IRD), Montpellier, France.
5
CNRS FR 3636, Université Paris Descartes, 75006, Paris, France. estaquier@yahoo.fr.
6
Centre de Recherche du CHU de Québec, Université Laval, Quebec, G1V 4G2, Canada. estaquier@yahoo.fr.
7
Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal. ricardosilvestre@ecsaude.uminho.pt.
8
ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal. ricardosilvestre@ecsaude.uminho.pt.

Abstract

Nicotinamide adenine dinucleotide (NAD(+)) is a vital molecule found in all living cells. NAD(+) intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD(+) metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD(+) metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD(+) homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD(+) or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD(+) metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases.

KEYWORDS:

Host-pathogen interaction; L-tryptophan; NAD+/NADH ratio; NADPH; Nicotinamide adenine dinucleotide (NAD+); Sirtuins

PMID:
26718485
DOI:
10.1007/s00018-015-2119-4
[Indexed for MEDLINE]

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