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Cytokine Growth Factor Rev. 2016 Apr;28:79-93. doi: 10.1016/j.cytogfr.2015.12.001. Epub 2015 Dec 15.

Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response.

Author information

1
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
2
Department of Computational Biophysics and Bioinformatics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
3
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. Electronic address: Joanna.Cichy@uj.edu.pl.

Abstract

Secretory leukocyte protease inhibitor (SLPI), a ∼12kDa nonglycosylated cationic protein, is emerging as an important regulator of innate and adaptive immunity and as a component of tissue regenerative programs. First described as an inhibitor of serine proteases such as neutrophil elastase, this protein is increasingly recognized as a molecule that benefits the host via its anti-proteolytic, anti-microbial and immunomodulatory activities. Here, we discuss the diverse functions of SLPI. Moreover, we review several novel layers of SLPI-mediated control that protect the host from excessive/dysregulated inflammation typical of infectious, allergic and autoinflammatory diseases and that support healing responses through affecting cell proliferation, differentiation and apoptosis.

KEYWORDS:

Allergy; Autoimmunity; Elastase; Inflammation; Protease

PMID:
26718149
DOI:
10.1016/j.cytogfr.2015.12.001
[Indexed for MEDLINE]

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