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Neurosci Lett. 1989 Jul 3;101(3):352-5.

A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles.

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1
Department of Neurology, University of Iowa College of Medicine, Iowa City 52242.

Abstract

Neurofibrillary tangles and neuritic plaques are the neuropathological hallmarks of Alzheimer's disease. The latter consist of a core of A4 amyloid protein. We now report that some neurofibrillary tangles ('tombstone tangles') are also A4 immunoreactive. This observation is consistent with the hypothesis that A4 amyloid accumulation is a component of both neurofibrillary tangles and neuritic plaques.

PMID:
2671814
[Indexed for MEDLINE]
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