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Oncol Rep. 2016 Feb;35(2):896-904. doi: 10.3892/or.2015.4445. Epub 2015 Nov 25.

Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway.

Author information

1
Centre of Laboratory Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China.
2
College of Life Science, Zhejiang University, Hangzhou, Zhejiang, P.R. China.

Abstract

Hispolon has been shown to have anticancer effects on various tumors. However, whether hispolon exerts anti-migration activity in breast cancer cells and the underlying mechanisms, have not been elucidated yet. In the present study, our data demonstrated that hispolon inhibited TPA-induced breast cancer MCF-7 cell migration at sub-toxic concentrations in vitro. Hispolon decreased the level of cellular ROS significantly and repressed TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), accompanied by upregulation of E-cadherin and downregulation of the transcriptional repressor Slug. Furthermore, N-acetyl-cysteine, an antioxidant agent, markedly suppressed TPA-induced epithelial-to-mesenchymal transition, cell migration and activation of ERK. Taken together, our results indicated that hispolon suppressed the migration of breast cancer cells via suppressing the ROS/ERK/Slug/E‑cadherin pathway. Hispolon may be developed as a potential antimetastasis agent to breast cancer.

PMID:
26718128
DOI:
10.3892/or.2015.4445
[Indexed for MEDLINE]

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