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Curr Oncol. 2015 Dec;22(6):e498-501. doi: 10.3747/co.22.2700.

Does CDKN2A loss predict palbociclib benefit?

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National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A.;


Palbociclib, an oral small-molecule inhibitor of cyclin-dependent kinases 4 and 6, was recently approved by the U.S. Food and Drug Administration in combination with letrozole for postmenopausal women with advanced hormone receptor-positive, her2-negative breast cancer. Patients with loss of CDKN2A (p16), an inherent negative regulator of cyclin-dependent kinases 4 and 6, were not separately studied because of the significant response of the patients selected based only on receptor status. Here, we report a patient with metastatic estrogen receptor- positive, her2-negative breast cancer with CDKN2A loss who experienced a clinical response to palbociclib.


Medical oncology; breast cancer

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