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Nutr J. 2015 Dec 29;14:127. doi: 10.1186/s12937-015-0117-x.

Relationship between daily isoflavone intake and sleep in Japanese adults: a cross-sectional study.

Author information

1
Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan. bigshowgod@yahoo.co.jp.
2
Department of Epidemiology, School of Public Health, Tianjin Medical University, Heping District, Tianjin, People's Republic of China. nkj0809@gmail.com.
3
Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan. hcongman@yahoo.com.
4
Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan. harupiyo326@hotmail.com.
5
Department of Medicine and Science in Sports and Exercise, Tohoku University Graduate School of Medicine, Sendai, Japan. guanlei09@hotmail.co.jp.
6
Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan. y-kobayashi@m.tains.tohoku.ac.jp.
7
Tianjin University of Sport, Tianjin, China. jpkakuki@yahoo.co.jp.
8
Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan. chuziyou.masahiko@xu31.fks.ed.jp.
9
Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan. ootomo@itamitoru.jp.
10
Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan. nagatomi@med.tohoku.ac.jp.

Abstract

BACKGROUND:

Isoflavones comprise a class of phytoestrogens that resemble human estrogen in chemical structure, and have weak estrogenic effects. Because estrogen modulates sleep duration and quality, we hypothesized that isoflavones would have a beneficial effect on sleep status in a way similar to estrogen. We conducted a cross-sectional study to investigate the relationship between daily isoflavone intake and sleep status in Japanese subjects.

METHODS:

Our study included 1076 Japanese adults aged 20-78 years. Daily isoflavone intake was assessed using a brief self-administered diet history questionnaire, and sleep was evaluated using a self-reported questionnaire.

RESULTS:

The prevalence of regular sleep duration (7-8 h/day) and sufficient sleep quality were 13.3% and 56.2%, respectively. After adjusting for potential confounding factors, the odds ratios (95% CIs) for optimal sleep duration (7-8 h) when higher isoflavone intakes (Q2-Q4) were compared with low isoflavone intake (Q1) were Q2: 0.94 (0.53-1.56); Q3: 1.28 (0.73-2.24); and Q4: 1.84 (1.06-3.18) (p for trend = 0.013). In the final adjusted model, sufficient sleep quality across categories of isoflavone intake was Q1: 1.00 (reference); Q2: 1.30 (0.91-1.84); Q3: 1.48 (1.03-2.12); and Q4: 1.78 (1.22-2.60); (p for trend = 0.002).

CONCLUSION:

Higher daily isoflavone intake was positively associated with optimal sleep duration and quality in a Japanese population. This finding suggests that daily isoflavone intake may have a potentially beneficial effect on sleep status.

PMID:
26715160
PMCID:
PMC4696198
DOI:
10.1186/s12937-015-0117-x
[Indexed for MEDLINE]
Free PMC Article

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