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Nat Rev Microbiol. 2016 Feb;14(2):93-105. doi: 10.1038/nrmicro.2015.8. Epub 2015 Dec 30.

The biogeography of polymicrobial infection.

Author information

1
Department of Molecular Biosciences, Institute of Cellular and Molecular Biology, Center for Infectious Disease, The University of Texas at Austin, 1 University Station A5000, Austin, Texas 78712, USA.
2
Centre for Immunity, Infection and Evolution, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3FL, UK.
3
School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA.

Abstract

Microbial communities are spatially organized in both the environment and the human body. Although patterns exhibited by these communities are described by microbial biogeography, this discipline has previously only considered large-scale, global patterns. By contrast, the fine-scale positioning of a pathogen within an infection site can greatly alter its virulence potential. In this Review, we highlight the importance of considering spatial positioning in the study of polymicrobial infections and discuss targeting biogeography as a therapeutic strategy.

PMID:
26714431
PMCID:
PMC5116812
DOI:
10.1038/nrmicro.2015.8
[Indexed for MEDLINE]
Free PMC Article

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