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Prog Biophys Mol Biol. 2016 Jan;120(1-3):249-54. doi: 10.1016/j.pbiomolbio.2015.12.007. Epub 2015 Dec 20.

Mechano-electric heterogeneity of the myocardium as a paradigm of its function.

Author information

1
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russia; Ural Federal University, Ekaterinburg, Russia. Electronic address: o.solovyova@iip.uran.ru.
2
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russia; Ural Federal University, Ekaterinburg, Russia. Electronic address: leonidkatsnelson51@gmail.com.
3
Research Centre for Cardiovascular Medicine, University of Freiburg, Germany; National Heart and Lung Institute, Imperial College of London, UK. Electronic address: kohl@imperial.ac.uk.
4
Department of Physics and Astronomy, Ghent University, Ghent, Belgium. Electronic address: Alexander.Panfilov@UGent.be.
5
Institute of Mechanics of Moscow State University, Russia. Electronic address: andrey.tsaturyan@gmail.com.
6
Ural State Medical University, Ekaterinburg, Russia. Electronic address: pavel.tsyvian@gmail.com.

Abstract

Myocardial heterogeneity is well appreciated and widely documented, from sub-cellular to organ levels. This paper reviews significant achievements of the group, led by Professor Vladimir S. Markhasin, Russia, who was one of the pioneers in studying and interpreting the relevance of cardiac functional heterogeneity.

KEYWORDS:

Cardiac modeling; Cardiomyocyte; Gradients in the cellular electrical and mechanical properties; Heart; Muscle duplex; Myocardial heterogeneity; Myocardial tissue; Slow force response; Wet and dry experiment

PMID:
26713555
PMCID:
PMC4821177
DOI:
10.1016/j.pbiomolbio.2015.12.007
[Indexed for MEDLINE]
Free PMC Article

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