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Int J Mol Sci. 2015 Dec 26;17(1). pii: E31. doi: 10.3390/ijms17010031.

RNA Binding Proteins in the miRNA Pathway.

Author information

1
Faculty of Science 1, University of Technology, Sydney, NSW 2007, Australia. patrick.connerty@student.uts.edu.au.
2
Faculty of Engineering and Information technology 2, University of Technology, Sydney, NSW 2007, Australia. alireza.ahadi@uts.edu.au.
3
Faculty of Engineering and Information technology 2, University of Technology, Sydney, NSW 2007, Australia. gyorgy.hutvagner@uts.edu.au.

Abstract

microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.

KEYWORDS:

Argonaute; Dicer; Drosha; RNA binding protein; cross-linking and immonoprecipitation (CLIP); miRNA

PMID:
26712751
PMCID:
PMC4730277
DOI:
10.3390/ijms17010031
[Indexed for MEDLINE]
Free PMC Article

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