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Molecules. 2015 Dec 26;21(1):E38. doi: 10.3390/molecules21010038.

Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review.

Author information

1
Department of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, Italy. gianmariafabrizio@yahoo.it.
2
Department of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, Italy. tizianacantile@yahoo.it.
3
Bambino Gesù Hospital, Division of Dentistry and Orthodontics, Rome 00165, Italy. tizianacantile@yahoo.it.
4
Department of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, Italy. brunella.alcidi@gmail.com.
5
Department of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, Italy. marcocoda@fastwebnet.it.
6
Department of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, Italy. ingenito@unina.it.
7
Department of Chemical Sciences, Complesso Universitario di Monte Sant'Angelo, Cupa Nuova Cintia, 21-80126-Napoli, University of Naples, Federico II, Naples 80126, Italy. armando.zarrelli@unina.it.
8
Inter-University Consortium "SannioTech", Apollosa (BN) 82030, Italy. armando.zarrelli@unina.it.
9
Department of Chemical Sciences, Complesso Universitario di Monte Sant'Angelo, Cupa Nuova Cintia, 21-80126-Napoli, University of Naples, Federico II, Naples 80126, Italy. giovanni.difabio@unina.it.
10
Department of Biology, Complesso Universitario di Monte Sant'Angelo, Cupa Nuova Cintia, 21-80126-Napoli, University of Naples, Federico II, Naples 80126, Italy. antonino.pollio@unina.it.

Abstract

Stevia rebaudiana Bertoni is a small perennial shrub of the Asteraceae (Compositae) family that is native to South America, particularly Brazil and Paraguay, where it is known as "stevia" or "honey leaf" for its powerful sweetness. Several studies have suggested that in addition to their sweetness, steviosides and their related compounds, including rebaudioside A and isosteviol, may offer additional therapeutic benefits. These benefits include anti-hyperglycaemic, anti-hypertensive, anti-inflammatory, anti-tumor, anti-diarrheal, diuretic, and immunomodulatory actions. Additionally, critical analysis of the literature supports the anti-bacterial role of steviosides on oral bacteria flora. The aim of this review is to show the emerging results regarding the anti-cariogenic properties of S. rebaudiana Bertoni. Data shown in the present paper provide evidence that stevioside extracts from S. rebaudiana are not cariogenic. Future research should be focused on in vivo studies to evaluate the effects on dental caries of regular consumption of S. rebaudiana extract-based products.

KEYWORDS:

Stevia rebaudiana Bertoni; dental caries; sweetener

PMID:
26712732
PMCID:
PMC6274104
DOI:
10.3390/molecules21010038
[Indexed for MEDLINE]
Free PMC Article

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