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Lasers Surg Med. 2016 Feb;48(2):174-80. doi: 10.1002/lsm.22461. Epub 2015 Dec 29.

Treatment of facial photodamage and rhytides using a novel 1,565 nm non-ablative fractional erbium-doped fiber laser.

Author information

1
Westlake Dermatology Clinical Research Center, Westlake Dermatology and Cosmetic Surgery, Austin, Texas, 78746.
2
Wall Street Dermatology, New York, New York, 10006.
3
New York Laser and Skin Care, New York, New York, 10028.
4
Cosmetic Laser Dermatology, San Diego, California, 92121.

Abstract

BACKGROUND AND OBJECTIVE:

Non-ablative fractional lasers (NAFL) generate microscopic non-contiguous columns of thermal injury in the dermis, resulting in collagen remodeling. This manuscript details our experience with a novel 1,565 nm scanned, erbium-doped fiber NAFL for the treatment of facial photodamage.

STUDY DESIGN/MATERIALS AND METHODS:

A prospective, open-label clinical trial was conducted at two clinical sites in the United States on 16 female subjects with a mean age of 49.6 years, Fitzpatrick skin types II to IV, and a baseline Fitzpatrick-Goldman Wrinkle and Elastosis Score (FGWES) of 3-6. Each subject received three treatments at 4-5 week intervals with follow-up assessments at 1, 3, and 6 months after the last treatment.

RESULTS:

The mean FGWES demonstrated a statistically significant decrease from baseline both at 3 months (-0.58 ± 0.23, P = 0.02) and 6 months (-0.66 ± 0.22, P = 0.008) after the last treatment. Fifty percent (95%CI [24.21%, 68.49%]) of subjects showed a significant (at least 1 grade) improvement in FGWES from baseline at 3-month follow-up. At least 72% of subjects perceived the results as "moderate" to "very good" at 3 months post-treatment, with comparable satisfaction rates. Treatments were not associated with a high level of pain or discomfort and typical downtime was less than 2 days. No unexpected adverse events or serious adverse events were reported.

CONCLUSION:

The 1,565 nm erbium-doped scanned NAFL is an effective treatment for facial wrinkles with a favorable recovery and side effect profile.

KEYWORDS:

fractional resurfacing; wrinkles

PMID:
26711809
DOI:
10.1002/lsm.22461
[Indexed for MEDLINE]

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