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J Cell Biol. 2016 Jan 4;212(1):9-11. doi: 10.1083/jcb.201512032. Epub 2015 Dec 28.

Cbx4: A new guardian of p63's domain of epidermal control.

Author information

1
Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
2
Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029 elena.ezhkova@mssm.edu.

Abstract

Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities.

PMID:
26711501
PMCID:
PMC4700485
DOI:
10.1083/jcb.201512032
[Indexed for MEDLINE]
Free PMC Article

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