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J Clin Endocrinol Metab. 2016 Mar;101(3):871-9. doi: 10.1210/jc.2015-3525. Epub 2015 Dec 28.

Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults.

Author information

1
Division of Metabolic and Nutritional Medicine (S.R., O.U., B.K., F.K., C.H.), Dr von Hauner Children's Hospital, Ludwig Maximilians University of Munich, D-80337 Munich, Germany; Royal Perth Hospital Unit (T.M., L.J.B.), School of Medicine and Pharmacology, The University of Western Australia, 6000 Perth, Western Australia, Australia; and Telethon Kids Institute (R.-C.H., W.H.O.), The University of Western Australia, 6009 Perth, Western Australia, Australia.

Abstract

CONTEXT:

Obesity and related diseases have become a global public health burden. Identifying biomarkers will lead to a better understanding of the underlying mechanisms associated with obesity and the pathways leading to insulin resistance (IR) and diabetes.

OBJECTIVE:

This study aimed to identify the lipidomic biomarkers associated with obesity and IR using plasma samples from a population-based cohort of young adults.

DESIGN AND SETTING:

The Western Australian Pregnancy Cohort (Raine) study enrolled 2900 pregnant women from 1989 to 1991. The 20-year follow-up was conducted between March 2010 and April 2012. Participants and Samples: Plasma samples from 1176 subjects aged 20 years were analyzed using mass spectrometry-based metabolomics.

MAIN OUTCOME MEASURES:

Associations of analytes with markers of obesity and IR including body mass index, waist circumference, homeostasis model assessment (HOMA-IR), and insulin were examined. Analyses were stratified by body mass index and adjusted for lifestyle and other factors.

RESULTS:

Waist circumference was positively associated with seven sphingomyelins and five diacylphosphatidylcholines and negatively associated with two lysophosphatidylcholines. HOMA-IR was negatively associated with two diacylphosphatidylcholines and positively with one lysophosphatidylcholine and one diacylphosphatidylcholine. No significant association was found in the obese/overweight group of the HOMA-IR model. In the normal-weight group, one lysophosphatidylcholine was increased.

CONCLUSION:

A possible discriminative effect of sphingomyelins, particularly those with two double bonds, and lysophosphatidylcholines was identified between subjects with normal weight and obesity independent of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol concentrations. Our results suggest weight status-dependent mechanisms for the development of IR with lysophosphatidylcholine C14:0 as a key metabolite in nonobese IR.

PMID:
26709969
DOI:
10.1210/jc.2015-3525
[Indexed for MEDLINE]

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