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Trends Biotechnol. 2016 Feb;34(2):156-170. doi: 10.1016/j.tibtech.2015.11.001. Epub 2015 Dec 18.

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening.

Author information

1
Department of Pharmacology and Toxicology, Radboudumc, PO Box 9101, Nijmegen, HB 6500 The Netherlands. Electronic address: martijn.wilmer@radboudumc.nl.
2
MIMETAS BV, JH Oortweg 19, Leiden, CH, 2333 The Netherlands.
3
University of Applied Sciences Northwestern Switzerland, School of Life Sciences, GrĂ¼ndenstrasse 40, 4132 Muttenz, Switzerland.
4
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, Utrecht, CG 3584 The Netherlands.

Abstract

Improved model systems to predict drug efficacy, interactions, and drug-induced kidney injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and DIKI. We also discuss high-throughput screening and the challenges for in vitro to in vivo extrapolation (IVIVE) that will need to be overcome for successful implementation.

KEYWORDS:

drug screening; high-throughput screening; kidney; microfluidics; nephrotoxicity; organ-on-a-chip

PMID:
26708346
DOI:
10.1016/j.tibtech.2015.11.001
[Indexed for MEDLINE]

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