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Curr Opin Microbiol. 2016 Feb;29:68-73. doi: 10.1016/j.mib.2015.11.005. Epub 2015 Dec 17.

Commensal 'trail of bread crumbs' provide pathogens with a map to the intestinal landscape.

Author information

1
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, 1340 Jefferson Park Ave., Charlottesville, VA 22908, USA.
2
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, 1340 Jefferson Park Ave., Charlottesville, VA 22908, USA. Electronic address: melissakendall@virginia.edu.

Abstract

Growth of a microorganism in a host is essential for infection, and bacterial pathogens have evolved to utilize specific metabolites to enhance replication in vivo. Now, emerging data demonstrate that pathogens rely on microbiota-derived metabolites as a form of bacterial-bacterial communication to gain information about location within a host and modify virulence gene expression accordingly. Thus, metabolite-sensing is critical for pathogens to establish infection. Here, we highlight recent examples of how the foodborne pathogen enterohemorrhagic Escherichia coli O157:H7 (EHEC) exploits microbiota-derived metabolites to recognize the host intestinal environment and control gene expression that results in controlled expression of virulence traits.

PMID:
26707739
PMCID:
PMC4755895
DOI:
10.1016/j.mib.2015.11.005
[Indexed for MEDLINE]
Free PMC Article

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