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Diagn Microbiol Infect Dis. 2016 Mar;84(3):184-6. doi: 10.1016/j.diagmicrobio.2015.11.019. Epub 2015 Nov 23.

Cross-reactivity between Lyme and syphilis screening assays: Lyme disease does not cause false-positive syphilis screens.

Author information

1
Department of Medicine, Nova Scotia Health Authority and Dalhousie University, Halifax, NS, Canada; Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Halifax, NS, Canada. Electronic address: glenn.patriquin@dal.ca.
2
Department of Medicine, Nova Scotia Health Authority and Dalhousie University, Halifax, NS, Canada; Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Halifax, NS, Canada; Department of Pathology, Dalhousie University, Halifax, NS, Canada.
3
Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Halifax, NS, Canada.
4
Public Health Agency of Canada (PHAC), National Microbiology Laboratory (NML), Winnipeg, MB, Canada.

Abstract

Increased rates of Lyme disease and syphilis in the same geographic area prompted an assessment of screening test cross-reactivity. This study supports the previously described cross-reactivity of Lyme screening among syphilis-positive sera and reports evidence against the possibility of false-positive syphilis screening tests resulting from previous Borrelia burgdorferi infection.

KEYWORDS:

Cross-reactivity; Lyme disease; Syphilis

[Indexed for MEDLINE]

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