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Head Neck. 2016 Apr;38 Suppl 1:E1886-95. doi: 10.1002/hed.24341. Epub 2015 Dec 26.

Intensity-modulated proton therapy for nasopharyngeal carcinoma: Decreased radiation dose to normal structures and encouraging clinical outcomes.

Author information

1
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
2
Department of Radiotherapy, Beykent University, Istanbul, Turkey.
3
Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas.

Abstract

BACKGROUND:

Intensity-modulated proton therapy (IMPT) has the potential to spare dose to organs at risk (OAR) when compared to intensity-modulated radiotherapy (IMRT) while maintaining excellent clinical outcomes.

METHODS:

Ten patients with nasopharyngeal carcinoma (NPC) were identified for whom IMPT was planned; 9 patients also had a comparison photon-based IMRT plan generated. Dosimetric comparison of mean radiation dose to 29 adjacent OAR was performed. Disease control, survival, and toxicity outcomes were collected from the medical records.

RESULTS:

There were significant differences in mean doses in 15 of the 29 OAR; 13 OAR received lower mean dose with proton-based plans. Median follow-up was 24.5 months (range, 19-32 months). Two-year locoregional control was 100% and the 2-year overall survival was 88.9%.

CONCLUSION:

We observed dosimetric advantages conferred by IMPT compared to IMRT. Further study is needed to determine if these translate into reduced toxicity and/or improved disease control. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1886-E1895, 2016.

KEYWORDS:

chemotherapy; clinical outcomes; dosimetric planning study; intensity-modulated proton therapy; nasopharyngeal carcinoma; radiotherapy

PMID:
26705956
DOI:
10.1002/hed.24341
[Indexed for MEDLINE]

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