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Adv Drug Deliv Rev. 2016 May 1;100:27-50. doi: 10.1016/j.addr.2015.12.010. Epub 2015 Dec 17.

Spray drying formulation of amorphous solid dispersions.

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Drug Delivery and Disposition, KU Leuven, Leuven, Belgium.
Drug Delivery and Disposition, KU Leuven, Leuven, Belgium. Electronic address:


Spray drying is a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water soluble drugs (PWSDs). However, the inherently complex nature of the spray drying process coupled with specific characteristics of ASDs makes it an interesting area to explore. Numerous diverse factors interact in an inter-dependent manner to determine the final product properties. This review discusses the basic background of ASDs, various formulation and process variables influencing the critical quality attributes (CQAs) of the ASDs and aspects of downstream processing. Also various aspects of spray drying such as instrumentation, thermodynamics, drying kinetics, particle formation process and scale-up challenges are included. Recent advances in the spray-based drying techniques are mentioned along with some future avenues where major research thrust is needed.


Amorphous solid dispersions; Downstream processing; Drying kinetics; Electrospraying; Mollier diagram; Poorly water soluble drugs; Scale-up; Spray drying

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