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Cell Res. 2016 Feb;26(2):149-50. doi: 10.1038/cr.2015.153. Epub 2015 Dec 25.

Organotropic metastasis: role of tumor exosomes.

Author information

1
National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.

Abstract

A recent paper in Nature shows that tumor exosomes expressing unique integrins can determine organotropic metastasis by preparing pre-metastatic niche through their integrins-mediated fusion with and fertilization of organ-specific resident cells.

PMID:
26704450
PMCID:
PMC4746605
DOI:
10.1038/cr.2015.153
[Indexed for MEDLINE]
Free PMC Article

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