Format

Send to

Choose Destination
Neuroscience. 2016 Feb 19;315:206-16. doi: 10.1016/j.neuroscience.2015.12.017. Epub 2015 Dec 14.

Mapping homeostatic synaptic plasticity using cable properties of dendrites.

Author information

1
Department of Pharmacology & Physiology, Georgetown University Medical Center, Washington, DC, United States; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC, United States; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States.
2
Department of Pharmacology & Physiology, Georgetown University Medical Center, Washington, DC, United States; Research Division, Korea Brain Research Institute, Daegu, Republic of Korea.
3
Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States.
4
Department of Pharmacology & Physiology, Georgetown University Medical Center, Washington, DC, United States; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC, United States.
5
Department of Pharmacology & Physiology, Georgetown University Medical Center, Washington, DC, United States; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC, United States. Electronic address: Daniel.Pak@georgetown.edu.

Abstract

When chronically silenced, cortical and hippocampal neurons homeostatically upregulate excitatory synaptic function. However, the subcellular position of such changes on the dendritic tree is not clear. We exploited the cable-filtering properties of dendrites to derive a parameter, the dendritic filtering index (DFI), to map the spatial distribution of synaptic currents. Our analysis indicates that young rat cortical neurons globally scale AMPA receptor-mediated currents, while mature hippocampal neurons do not, revealing distinct homeostatic strategies between brain regions and developmental stages. The DFI presents a useful tool for mapping the dendritic origin of synaptic currents and the location of synaptic plasticity changes.

KEYWORDS:

AMPA receptors; current shape; dendritic filtering index; dendritic origin; homeostatic synaptic plasticity; mEPSC slope

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center