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Brain Struct Funct. 2016 Dec;221(9):4369-4382. Epub 2015 Dec 23.

Gray matter responsiveness to adaptive working memory training: a surface-based morphometry study.

Author information

1
Universidad Autónoma de Madrid, 28049, Madrid, Spain.
2
Montreal Neurological Institute (MNI), McGill University, Montreal, Canada.
3
University of California, San Diego, USA.
4
Universidad Pompeu Fabra, Barcelona, Spain.
5
Hospital Gregorio Marañon, Madrid, Spain.
6
University of California at Irvine, Irvine, USA.
7
Universidad Autónoma de Madrid, 28049, Madrid, Spain. roberto.colom@uam.es.

Abstract

Here we analyze gray matter indices before and after completing a challenging adaptive cognitive training program based on the n-back task. The considered gray matter indices were cortical thickness (CT) and cortical surface area (CSA). Twenty-eight young women (age range 17-22 years) completed 24 training sessions over the course of 3 months (12 weeks, 24 sessions), showing expected performance improvements. CT and CSA values for the training group were compared with those of a matched control group. Statistical analyses were computed using a ROI framework defined by brain areas distinguished by their genetic underpinning. The interaction between group and time was analyzed. Middle temporal, ventral frontal, inferior parietal cortices, and pars opercularis were the regions where the training group showed conservation of gray matter with respect to the control group. These regions support working memory, resistance to interference, and inhibition. Furthermore, an interaction with baseline intelligence differences showed that the expected decreasing trend at the biological level for individuals showing relatively low intelligence levels at baseline was attenuated by the completed training.

KEYWORDS:

Brain plasticity; Cognitive training; Cortical surface area; Cortical thickness; Surface-based morphometry

PMID:
26701168
PMCID:
PMC4919225
DOI:
10.1007/s00429-015-1168-7
[Indexed for MEDLINE]
Free PMC Article

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