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BMJ Open. 2015 Dec 23;5(12):e008828. doi: 10.1136/bmjopen-2015-008828.

First results about recovery of walking function in patients with intensive care unit-acquired muscle weakness from the General Weakness Syndrome Therapy (GymNAST) cohort study.

Author information

1
Wissenschaftliches Institut, Private Europäische Medizinische Akademie der Klinik Bavaria in Kreischa, Kreischa, Germany Department of Public Health, Medizinische Fakultät 'Carl Gustav Carus', Technische Universität Dresden, Dresden, Germany.
2
Wissenschaftliches Institut, Private Europäische Medizinische Akademie der Klinik Bavaria in Kreischa, Kreischa, Germany.
3
Fach und Privatkrankenhaus, Klinik Bavaria in Kreischa, Kreischa, Germany.

Abstract

OBJECTIVES:

To describe the time course of recovery of walking function and other activities of daily living in patients with intensive care unit (ICU)-acquired muscle weakness.

DESIGN:

This is a cohort study.

PARTICIPANTS:

We included critically ill patients with ICU-acquired muscle weakness.

SETTING:

Post-acute ICU and rehabilitation units in Germany.

MEASURES:

We measured walking function, muscle strength, activities in daily living, motor and cognitive function.

RESULTS:

We recruited 150 patients (30% female) who fulfilled our inclusion and exclusion criteria. The primary outcome recovery of walking function was achieved after a median of 28.5 days (IQR=45) after rehabilitation onset and after a median of 81.5 days (IQR=64) after onset of illness. Our final multivariate model for recovery of walking function included two clinical variables from baseline: the Functional Status Score ICU (adjusted HR=1.07 (95% CI 1.03 to 1.12) and the ability to reach forward in cm (adjusted HR=1.02 (95% CI 1.00 to 1.04). All secondary outcomes but not pain improved significantly in the first 8 weeks after study onset.

CONCLUSIONS:

We found good recovery of walking function for most patients and described the recovery of walking function of people with ICU-acquired muscle weakness.

TRIALS REGISTRATIONS NUMBER:

Sächsische Landesärztekammer EK-BR-32/13-1; DRKS00007181, German Register of Clinical Trials.

KEYWORDS:

REHABILITATION MEDICINE

PMID:
26700274
PMCID:
PMC4691758
DOI:
10.1136/bmjopen-2015-008828
[Indexed for MEDLINE]
Free PMC Article

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