A palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines

Org Biomol Chem. 2016 Feb 7;14(5):1665-9. doi: 10.1039/c5ob02514a.

Abstract

A facile route to synthesise N-aminosulfonamides through a palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines is reported. This transformation proceeds in the presence of Pd(OAc)2/XantPhos, and TBAB in 1,4-dioxane at 80 °C, leading to the corresponding N-aminosulfonamides in moderate to good yields. The reaction scope has been demonstrated, and good functional tolerance is observed. A plausible mechanism is proposed through the insertion of sulfur dioxide.

Publication types

  • Research Support, Non-U.S. Gov't