Format

Send to

Choose Destination
Dev Dyn. 2016 Mar;245(3):351-60. doi: 10.1002/dvdy.24379. Epub 2016 Jan 13.

Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis.

Author information

1
McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania.
2
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
3
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania.

Abstract

During normal morphogenesis the extracellular matrix (ECM) influences cell motility, proliferation, apoptosis, and differentiation. Tissue engineers have attempted to harness the cell signaling potential of ECM to promote the functional reconstruction, if not regeneration, of injured or missing adult tissues that otherwise heal by the formation of scar tissue. ECM bioscaffolds, derived from decellularized tissues, have been used to promote the formation of site appropriate, functional tissues in many clinical applications including skeletal muscle, fibrocartilage, lower urinary tract, and esophageal reconstruction, among others. These scaffolds function by the release or exposure of growth factors and cryptic peptides, modulation of the immune response, and recruitment of progenitor cells. Herein, we describe this process of ECM induced constructive remodeling and examine similarities to normal tissue morphogenesis.

KEYWORDS:

bioscaffold; extracellular matrix; tissue remodeling

PMID:
26699796
PMCID:
PMC4755921
[Available on 2017-03-01]
DOI:
10.1002/dvdy.24379
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center