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J Microbiol Biotechnol. 2016 Mar;26(3):483-7. doi: 10.4014/jmb.1512.12018.

Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia.

Author information

1
Korea Yakult Co., Ltd., Yongin 17086, Republic of Korea.
2
Graduate School of International Agricultural Technology, Institute of Green Bio Science & Technology, Seoul National University, Pyeongchang 25354, Republic of Korea.
3
Division of Gastroenterology, Vievis NAMUH Hospital, Seoul 06117, Republic of Korea.

Abstract

The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 X 10(9) CFU/day of L. plantarum KY1032 and 5 X 10(9) CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPARĪ±, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPARĪ±, and FXR.

KEYWORDS:

Lactobacillus curvatus; Lactobacillus plantarum; Triglyceride; apolipoprotein A-V; probiotics

PMID:
26699746
DOI:
10.4014/jmb.1512.12018
[Indexed for MEDLINE]
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