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BMC Genet. 2015 Dec 23;16:147. doi: 10.1186/s12863-015-0319-4.

Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study.

Author information

1
National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. sharon.davis@nih.gov.
2
National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. ruihua.xu@nih.gov.
3
National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. samson.gebreab@nih.gov.
4
National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. teresa.riestra@nih.gov.
5
National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. amadou.gaye@nih.gov.
6
National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. rumana.khan@nih.gov.
7
Department of Physiology, University of Mississippi Center, 2500 N State St, Jackson, MS, 39216, USA. jgwilson2@umc.edu.
8
Indiana University Bloomington, School of Public Health, 1025 E. 7th St, Suite 111, Bloomington, IN, 47405, USA. abidules@indiana.edu.

Abstract

BACKGROUND:

African Americans experience disproportionately higher prevalence of type 2 diabetes and related risk factors. Little research has been done on the association of ADIPOQ gene on type 2 diabetes, plasma adiponectin, blood glucose, HOMA-IR and body mass index (BMI) in African Americans. The objective of our research was to assess such associations with selected SNPs. The study included a sample of 3,020 men and women from the Jackson Heart Study who had ADIPOQ genotyping information. Unadjusted and adjusted regression models with covariates were used with type 2 diabetes and related phenotypes as the outcome stratified by sex.

RESULTS:

There was no association between selected ADIPOQ SNPs with type 2 diabetes, blood glucose, or BMI in men or women. There was a significant association between variant rs16861205 and lower adiponectin in women with minor allele A in the fully adjusted model (β(SE) p = -.13(0.05), 0.003). There was also a significant association with variant rs7627128 and lower HOMA-IR among men with minor allele A in the fully adjusted model (β(SE) p = -0.74(0.20), 0.0002).

CONCLUSIONS:

These findings represent new insights regarding the association of ADIPOQ gene and type 2 diabetes and related phenotypes in African American men and women.

PMID:
26699120
PMCID:
PMC4690307
DOI:
10.1186/s12863-015-0319-4
[Indexed for MEDLINE]
Free PMC Article

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