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Fertil Steril. 2016 Mar;105(3):781-785. doi: 10.1016/j.fertnstert.2015.11.034. Epub 2015 Dec 14.

Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.

Author information

1
International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
2
CReATe Fertility Centre, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
3
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
4
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, West Hollywood, California.
5
Beth Israel Deaconess Medical Center, Boston, Massachusetts.
6
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California.
7
Research Group Inherited Cancer, Department of Medical, Genetics, Oslo University Hospital, Oslo, Norway.
8
London Regional Cancer Program, London, Ontario, Canada.
9
Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
10
Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada. Electronic address: steven.narod@wchospital.ca.

Abstract

OBJECTIVE:

To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.

DESIGN:

A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer.

SETTING:

Genetic clinics.

PATIENT(S):

Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment.

RESULT(S):

There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer.

CONCLUSION(S):

Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.

KEYWORDS:

BRCA1; BRCA2; infertility; in vitro fertilization; ovarian cancer

[Indexed for MEDLINE]

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