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Head Neck. 2016 Apr;38 Suppl 1:E1788-93. doi: 10.1002/hed.24316. Epub 2015 Dec 24.

Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers.

Author information

1
Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
2
Department of Otorhinolaryngology - Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University, College of Medicine, Seoul, South Korea.

Abstract

BACKGROUND:

The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer.

METHODS:

The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade.

RESULTS:

Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively).

CONCLUSION:

Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1788-E1793, 2016.

KEYWORDS:

grade; locoregional; parotid cancer; recurrence; survival

PMID:
26698329
DOI:
10.1002/hed.24316
[Indexed for MEDLINE]

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